A phosphine-mediated stereocontrolled synthesis of Z-enediynes by a vicinal dialkynylation of ethynylphosphonium salts.

نویسندگان

  • Kyle D Reichl
  • Alexander T Radosevich
چکیده

Z-Enediynes are prepared by a vicinal dialkynylation of triaryl(arylethynyl)phosphonium cations. The method, which proceeds under mild transition metal-free conditions, can be conducted on multigram scale as a one-pot, phosphine-mediated synthetic cycle giving enediyne products with excellent control of configuration.

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عنوان ژورنال:
  • Chemical communications

دوره 50 66  شماره 

صفحات  -

تاریخ انتشار 2014